Neil Josephson in

Neil Josephson

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Chief Medical Officer at Iambic Therapeutics
📍 Seattle, Washington, United States

Neil Josephson is the Chief Medical Officer at Iambic Therapeutics, an AI-driven drug discovery company. A physician-scientist trained in oncology and hematology at Columbia University, he has extensive experience leading clinical development. He previously held senior roles at Zymeworks and Seagen, where he led successful programs for HER2-targeted therapies and Hodgkins Lymphoma.

Before entering the biopharmaceutical industry, he served as an Associate Professor of Medicine at the University of Washington, where he remains a Clinical Associate Professor. He has also publicly committed to the role of physicians in discussing public health topics, including firearm safety, with patients when risk factors are present.

He is now leading a clinical trial at Iambic that involves a combination with zanidatamab, the same HER2-targeted bispecific antibody whose development he led at his former company, Zymeworks.

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Experience
22 Years
Current Role
Chief Medical Officer
Job Level
Leadership
Location
Seattle, Washington, United States
Personality Overview

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Communication Style
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Priorities

Topics Neil cares about

AI in Drug Discovery
As CMO of Iambic Therapeutics, he is at the forefront of using a proprietary AI platform to develop novel medicines with unprecedented speed and precision.
HER2-Targeted Therapies
He has a deep focus on HER2-driven cancers, having led the development of the bispecific antibody zanidatamab at Zymeworks and now the inhibitor IAM1363 at Iambic.
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Career

Work history

1-2024
Chief Medical Officer
Iambic Therapeutics
11-2021 - 1-2023
Chief Medical Officer
Zymeworks Inc.
9-2020 - 11-2021
Senior Vice President, Clinical Research
Zymeworks Inc.
4-2019 - 8-2020
Vice President, Clinical Research
Zymeworks Inc.
11-2018 - 4-2019
Vice President, Clinical Development
Seattle Genetics
In the press

Media appearances

Iambic Therapeutics expands leadership team with the appointment of Neil Josephson, MD as Chief Medical Officer. Featured in Iambic.ai (company blog)
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Iambic Shares Clinical Data from Ph1/1B Study of IAM1363, a Highly Selective Type‑2 HER2 Inhibitor Demonstrating Monotherapy Activity in Heavily Pretreated Patients with HER2 Alterations at the 2025 ESMO Congress. Featured in Business Wire
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Education
Doctor of Medicine - MD
Columbia University
AB
Dartmouth College
Social presence
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Behavioral profile

DISC profile (public)

DISC behavioral profile

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