Donna-Lee Destouche, M.Sc., CCRP in

Donna-Lee Destouche, M.Sc., CCRP

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VP, Head of Clinical Operations at Prothena Corporation
📍 Cambridge, Massachusetts, United States

As VP, Head of Clinical Operations at Prothena, Donna-Lee Destouche leads the strategic execution of clinical trials. Her experience includes managing trials from Phase I to III for gene therapy and RNA-targeted treatments. She holds a Master of Science from Emmanuel College and a Bachelors from Boston University.

Donna-Lee is a vocal advocate for supporting women and girls in science. She has shared public perspectives and written an open letter to inspire young women entering STEM fields, showing a clear passion for mentorship and representation in her industry.

She is a public advocate for both women entering STEM and for raising awareness around rare diseases.

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Experience
14 Years
Current Role
VP, Head of Clinical Operations
Job Level
Senior
Location
Cambridge, Massachusetts, United States
Personality Overview

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Communication Style
Decision Approach
Work Preference

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Priorities

Topics Donna-Lee cares about

Clinical Trial Operations
Leads clinical operations at Prothena and previously managed trials from Phase I to III at Sarepta Therapeutics, focusing on strategic planning and execution.
Neurodegenerative Diseases
Her work at Prothena is centered on developing therapies for diseases like Alzheimer's and Parkinson's, indicating deep expertise in this area.
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Career

Work history

1-2025
VP, Head of Clinical Operations
Prothena Corporation
3-2024 - 1-2025
VP, Head of Clinical Trial Management
Prothena Corporation
2-2022 - 3-2024
Senior Director, Clinical Trial Operations
Prothena Corporation
4-2020 - 1-2022
Director, Clinical Operations
Sarepta Therapeutics
8-2018 - 4-2020
Associate Director, Clinical Operations
Sarepta Therapeutics
In the press

Media appearances

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Education
Bachelor of Arts and Science
Boston University
Masters of Science
Emmanuel College (Boston)
Social presence
in
Behavioral profile

DISC profile (public)

DISC behavioral profile

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