Donna-Lee Destouche, M.Sc., CCRP

Commander
DISC Type : D

VP, Head of Clinical Operations at Prothena Corporation

Cambridge, Massachusetts, United States

Overview

As VP, Head of Clinical Operations at Prothena, Donna-Lee Destouche leads the strategic execution of clinical trials. Her experience includes managing trials from Phase I to III for gene therapy and RNA-targeted treatments. She holds a Master of Science from Emmanuel College and a Bachelors from Boston University.

Donna-Lee is a vocal advocate for supporting women and girls in science. She has shared public perspectives and written an open letter to inspire young women entering STEM fields, showing a clear passion for mentorship and representation in her industry.

She is a public advocate for both women entering STEM and for raising awareness around rare diseases.

Personality Overview

Very Quick

Strong-Willed

Candid & Clear

They do not care very much about building rapport or relationships.  They like to stay in control of the negotiation or defining of the terms. They respond better to strong and respectful interactions.

Topics They Care About

Clinical Trial Operations
Leads clinical operations at Prothena and previously managed trials from Phase I to III at Sarepta Therapeutics, focusing on strategic planning and execution.
Neurodegenerative Diseases
Her work at Prothena is centered on developing therapies for diseases like Alzheimer's and Parkinson's, indicating deep expertise in this area.
Women in STEM
Publicly shares her perspective on supporting women and girls in science and has authored an open letter to encourage them.

Media Appearances

Donna-Lee has no verified media appearances

Work History

1-2025
VP, Head of Clinical Operations at Prothena Corporation
3-2024 - 1-2025
VP, Head of Clinical Trial Management at Prothena Corporation
2-2022 - 3-2024
Senior Director, Clinical Trial Operations at Prothena Corporation
4-2020 - 1-2022
Director, Clinical Operations at Sarepta Therapeutics
8-2018 - 4-2020
Associate Director, Clinical Operations at Sarepta Therapeutics

Education

Bachelor of Arts and Science from Boston University
Masters of Science from Emmanuel College (Boston)

More Information

Social Presence :

Prographics :

Exp : 14 Location : Cambridge, Massachusetts, United States Job Level : Senior Designation : VP, Head of Clinical Operations at Prothena Corporation
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Insights For Selling To Donna-Lee

During A Call Or A Meeting

DO's

  • Make sure that you circle back fast on any action items, it wins their trust
  • Refer to testimonials from well-known industry leaders
  • Objectively showcase the impact that your product creates

DONT's

  • Do not back off when challenged, respond with a confident, objective answer instead
  • Don't try too hard to forge relationships with them
  • Do not hesitate from asking counter questions, just avoid challenging their authority

When Cold Calling

When Writing An Email

While Negotiating & Closing

    The secret to closing fast with Donna-Lee is

  • Conviction around the impact matters the most to them, followed by a sense of achievement and ROI.
  • Will you ever get a clear answer from Donna-Lee

  • If they are not convinced, they will say no without any hesitation.

Insights For Deal Planning

    How fast (or slow) will Donna-Lee move?

  • If convinced, they can reach decisions quite fast.
  • Can Donna-Lee take some risk or not?

  • They do not shy away from taking risks, but can be quite binary about them.

You And Donna-Lee

Personality Compatibility


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