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Topher Brooke

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CEO, Board Director at MasterSwitch Bio
📍 Greater Philadelphia, United States

Topher Brooke is a biopharmaceutical executive with over 25 years of experience leading venture-backed and public companies. As CEO of MasterSwitch Bio, he advances pioneer mRNA therapeutics. He previously served as COO for SwanBio Therapeutics and Aytu BioPharm, demonstrating a track record of building and exiting companies and advancing first-in-class therapies.

He serves on the Board of Advisors for Life Science Cares Philadelphia, an organization with a mission to disrupt the cycle of poverty and inequality in local communities. This role reflects his commitment to ensuring access to basic needs, education, and opportunity for everyone.

His current company, MasterSwitch Bio, was co-founded by 2023 Nobel Prize winner Dr. Drew Weissman to reverse end-stage liver disease.

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Experience
26 Years
Current Role
CEO, Board Director
Job Level
Leadership
Location
Greater Philadelphia, United States
Personality Overview

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Communication Style
Decision Approach
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Priorities

Topics Topher cares about

mRNA Therapeutics
As CEO of MasterSwitch Bio, he is leading the development of transcription factor mRNA therapeutics to rescue end-stage organs, co-founded by Nobel laureate Drew Weissman.
Rare Disease Therapies
He founded Rumpus Therapeutics, focusing on rare pediatric diseases, and has held executive roles at Aytu BioPharm and SwanBio, advancing therapies for rare conditions like vEDS and AMN.
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Career

Work history

11-2024
CEO, Board Director
MasterSwitch Bio
10-2023 - 8-2024
Chief Operating Officer
SwanBio Therapeutics
11-2022 - 10-2023
Chief Operating Officer
Aytu BioPharma
8-2022
Member of The Board of Advisors
Life Science Cares Philadelphia
4-2021 - 10-2022
Executive Vice President, Rare Disease Development
Aytu BioPharma
In the press

Media appearances

MasterSwitch Bio: The New Ambler Startup Aiming to Reverse Liver Damage. Featured in MSN.com
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Education
2002 - 2004
MBA
The Wharton School
1993 - 1997
Bachelor of Arts
Colgate University
Social presence
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Behavioral profile

DISC profile (public)

DISC behavioral profile

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