Topher Brooke

Enthusiast
DISC Type : i

CEO, Board Director at MasterSwitch Bio

Greater Philadelphia, United States

Overview

Topher Brooke is a biopharmaceutical executive with over 25 years of experience leading venture-backed and public companies. As CEO of MasterSwitch Bio, he advances pioneer mRNA therapeutics. He previously served as COO for SwanBio Therapeutics and Aytu BioPharm, demonstrating a track record of building and exiting companies and advancing first-in-class therapies.

He serves on the Board of Advisors for Life Science Cares Philadelphia, an organization with a mission to disrupt the cycle of poverty and inequality in local communities. This role reflects his commitment to ensuring access to basic needs, education, and opportunity for everyone.

His current company, MasterSwitch Bio, was co-founded by 2023 Nobel Prize winner Dr. Drew Weissman to reverse end-stage liver disease.

Personality Overview

Non-Confrontational

Amiable & Agreeable

Story Driven

Unlike D or C types, they are convinced more by stories and testimonials.  They are more about building relationships than just cutting deals. They agree with others often, so exercise caution when relying on their word.

Topics They Care About

mRNA Therapeutics
As CEO of MasterSwitch Bio, he is leading the development of transcription factor mRNA therapeutics to rescue end-stage organs, co-founded by Nobel laureate Drew Weissman.
Rare Disease Therapies
He founded Rumpus Therapeutics, focusing on rare pediatric diseases, and has held executive roles at Aytu BioPharm and SwanBio, advancing therapies for rare conditions like vEDS and AMN.
Gene Therapy
As COO of SwanBio Therapeutics, he was deeply involved in advancing AAV-based gene therapies for inherited neurological conditions, particularly those affecting the central nervous system.

Media Appearances

MasterSwitch Bio: The New Ambler Startup Aiming to Reverse Liver Damage. Featured in MSN.com

See Now

Work History

11-2024
CEO, Board Director at MasterSwitch Bio
10-2023 - 8-2024
Chief Operating Officer at SwanBio Therapeutics
11-2022 - 10-2023
Chief Operating Officer at Aytu BioPharma
8-2022
Member of The Board of Advisors at Life Science Cares Philadelphia
4-2021 - 10-2022
Executive Vice President, Rare Disease Development at Aytu BioPharma

Education

2002 - 2004
MBA from The Wharton School
1993 - 1997
Bachelor of Arts from Colgate University

More Information

Social Presence :

Prographics :

Exp : 26 Location : Greater Philadelphia, United States Job Level : Leadership Designation : CEO, Board Director at MasterSwitch Bio
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Insights For Selling To Topher

During A Call Or A Meeting

DO's

  • Maintain high, positive energy and convey confidence
  • Speak from experience about success that the product has seen with other customers
  • Refer to interesting customer testimonials and stress on great customer experience

DONT's

  • Don’t ask too many questions in one go, weave them into the flow
  • Avoid overloading them with too much information
  • Don’t be too formal with them, they trust informality more

When Cold Calling

When Writing An Email

While Negotiating & Closing

    The secret to closing fast with Topher is

  • Relationships and rapport matter to them, but so does the value of the product.
  • Will you ever get a clear answer from Topher

  • They probably won't say no directly.


Insights For Deal Planning

    How fast (or slow) will Topher move?

  • They are not the ones to make fast decisions, even while they stay committed.
  • Can Topher take some risk or not?

  • If it seems really necessary, they can take small risks.

You And Topher

Personality Compatibility


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